Abstract
A series of amplitude and spectral studies was performed to investigate brain cortical activity in rats with traumatized brain (open penetrating traumatic brain injury (TBI)). Electrocorticograms (ECoG) were recorded on the 3rd and the 7th day following the trauma. An amplitude analysis comprised an estimation of the mean signal amplitude and the degree of Lempel — Ziv compression. A spectral analysis involved a calculation of the mean amplitude and δ-, θ-, α- and β-rhythm indices. Characteristic changes in the ECoG amplitude and spectral parameters were revealed in TBI rats. Traumatized animals demonstrated decreased values of both the mean signal amplitude, as well as the amplitudes and indices of θ-, α- and β-rhythms. At the same time, the mean amplitude and the index of delta-frequency were increased. Similar changes were observed not only near the traumatized area but also in the other brain cortex regions on the 3rd and 7th day following the trauma. The obtained results demonstrate that the investigated TBI model has numerous electro physiological similarities with traumas in clinical practice, thus being applicable for neurophysiological and pharmacological studies.
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