Genuine MMN, memory-based comparison, and neural adaptation

Abstract

Event Abstract Back to Event Genuine MMN, memory-based comparison, and neural adaptation Thomas Jacobsen1* 1 Institut für Psychologie I, Universität Leipzig , Germany Human EEG and MEG recordings have been employed to generate the bulk of research on the Mismatch Negativity (MMN). These non-invasive measures of large-scale neural brain activity are very often used as physiological correlates of mental information processing, as correlates informing cognitive architecture. This presentation will also pursue this venue, and attempt to relate the former measures to the latter cognitive models. The MMN is an electromagnetic response to any detected deviation in regular auditory input. For instance, changes in the pitch of repetitive sounds elicit the MMN. There exist two alternative accounts for this index of automatic change detection in this situation: (1) A sensorial, non-comparator account according to which ERPs in oddball sequences are affected by differential refractory states of frequency-specific afferent cortical neurons. (2) A cognitive, comparator account stating that MMN reflects the outcome of a memory-based comparison between a cognitive regularity representation constructed based on the frequently presented standard sound with the sensory memory representation of the deviating sound. In a series of studies, we had set out to investigate this issue. Using a condition controlling for refractoriness effects, the two contributions to MMN can be disentangled. One of our studies used whole-head MEG to further elucidate the sensorial and cognitive contributions to frequency MMN. Results replicated ERP findings that MMN to pitch change is a compound of the activity reflecting a sensorial, non-comparator mechanism and a cognitive, comparator mechanism when a deviant-minus-standard subtraction is used. Using the controlled protocol these N1 and genuine MMN contributions could be separated in time. The sensorial part of frequency MMN consisting of spatially dipolar patterns was maximal in the late N1 range (105-125 ms), while the cognitive part peaked in the late MMN-range (170-200 ms). Spatial principal component analyses revealed that the early part of the traditionally measured MMN (deviant minus standard) is mainly due to the sensorial mechanism while the later mainly due to the cognitive mechanism. Inverse modeling revealed sources for both MMN contributions in the gyrus temporales transversus, bilaterally. These MEG results suggest temporally distinct but spatially overlapping activities of non-comparator-based and comparator-based mechanisms of automatic frequency change and deviance detection. In addition, the presentation will also touch upon other pieces of empirical evidence suggesting that the genuine MMN and the adaptation account, i.e. the differential activation of the afferent N1 transient detectors, when measured with EEG/MEG and in a suitable way, reflect distinct cognitive mechanisms. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Workshop 2: The role of adaptation in deviance detection Citation: Jacobsen T (2009). Genuine MMN, memory-based comparison, and neural adaptation. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.015 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Mar 2009; Published Online: 19 Mar 2009. * Correspondence: Thomas Jacobsen, Institut für Psychologie I, Universität Leipzig, Leipzig, Germany, jacobsen@uni-leipzig.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Thomas Jacobsen Google Thomas Jacobsen Google Scholar Thomas Jacobsen PubMed Thomas Jacobsen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.