CORTICAL AND SUBCORTICAL CONTRIBUTION TO THE AUDITORY AUTOMATIC CHANGE DETECTION: AN ELECTRA MISMATCH NEGATIVITY STUDY.

Abstract

Event Abstract Back to Event CORTICAL AND SUBCORTICAL CONTRIBUTION TO THE AUDITORY AUTOMATIC CHANGE DETECTION: AN ELECTRA MISMATCH NEGATIVITY STUDY. Diego Lozano-Soldevilla1*, R. Grave De Peralt1, 2, Lluis Fuentemilla3 and C. Grau1 1 Psychiatry and Clinic Psychobiology Department. University of Barcelona, Spain 2 Electrical Neuroimaging Group. Neurology Department. Geneva University Hospitals, Switzerland 3 Institute of Cognitive Neuroscience. University College of London, United Kingdom The brain regions that support the MMN auditory potential in humans are not fully understood. The use of classical noninvasive methods in humans has repeatedly identified several sparse generators of MMN, manly in supratemporal and frontal cortex. However, intracortical electrophysiological recordings in animals and humans support that the mechanisms of auditory sensory memory and change detection may also involve subcortical structures such as basal ganglia and hippocampus.This study explored in 16 healthy young subjects the cerebral generators of MMN by the use of the ELECTRA inverse solution approach. This allows the noninvasive estimation of intracranial potentials from scalp EEG data, based on the irrotational character of the electrical currents generating the EEG. Indeed, ELECTRA already demonstrated to be sensible to deep brain electrophysiological sources in ERP studies (Grave de Peralta, 2006, IJBEM,8,1-18 ). Here, we found that in addition to the classic MMN cortical sources, we could non-invasively also capture in humans some subcortical contributions such as hippocampus, thalamus and pallidum. Having access, noninvasively and in humans, to additional subcortical sources contributing to MMN could help in understanding the complex circuitry underlying auditory sensory memory and their link to brain diseases in which MMN is altered.This study was supported by grants of Ministerio de Ciencia y Tecnología (SEJ2006-13998) and Fundació la Marató (2006- 061632). Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: Lozano-Soldevilla D, Grave De Peralt R, Fuentemilla L and Grau C (2009). CORTICAL AND SUBCORTICAL CONTRIBUTION TO THE AUDITORY AUTOMATIC CHANGE DETECTION: AN ELECTRA MISMATCH NEGATIVITY STUDY.. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.155 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Mar 2009; Published Online: 26 Mar 2009. * Correspondence: Diego Lozano-Soldevilla, Psychiatry and Clinic Psychobiology Department. University of Barcelona, Barcelona, Spain, dlozano@ub.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Diego Lozano-Soldevilla R. Grave De Peralt Lluis Fuentemilla C. Grau Google Diego Lozano-Soldevilla R. Grave De Peralt Lluis Fuentemilla C. Grau Google Scholar Diego Lozano-Soldevilla R. Grave De Peralt Lluis Fuentemilla C. Grau PubMed Diego Lozano-Soldevilla R. Grave De Peralt Lluis Fuentemilla C. Grau Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.