Reduced duration MMN and impaired temporal integration window in clinical populations

Abstract

Event Abstract Back to Event Reduced duration MMN and impaired temporal integration window in clinical populations Hirooki Yabe1* 1 Department of Neuropsychiatry, Fukushima Medical University, Japan The acoustic brain has probably developed the defensive mechanism for survival in the primeval forest. With this mechanism as reflected by the mismatch negativity (MMN), we can detect abnormal sounds coming from the dangerous events even when doing something else. MMN has attracted many researchers' attention for years, because it is considered to reflect the memory-based processing (Näätänen, 1992). MMN should be generated by the comparison process between sound deviation and neural trace of preceding sounds stored in auditory sensory memory. A large amount of previous studies provided evidence for the memory-based interpretation of MMN, “memory trace theory”. Our previous findings of MMN being elicited by sound omission also strongly supported this theory, because no afferent neurons could be activated by physical absence, “omission”. In addition, those studies provided new evidence for the other brain mechanism termed Temporal Window of Integration (TWI). The brain is considered to integrate the closely (<200 ms) presented sounds into single information units. MMN to occasional omission in repetitive tones were elicited only with SOAs shorter than 160 ms, suggesting a temporal correspondence between the duration of the neural sound-representations in sensory memory and the TWI of 160-170 ms. What was represented as the standard event was not single stimulus but rather a compound stimulus. Furthermore, sound trace is considered to be represented as time-functional information of the auditory scene. On the other hand, MMN provides a useful measure for clinical populations, because MMN generation does not require any tasks. MMN can be elicited by various types of sound deviations. Most interestingly, MMN to duration deviation is exceptionally sensitive to many clinical populations such as coma, Alzheimer disease, schizophrenia, and so on. Michie et al. (2000) reported that only duration-MMN was reliably reduced in patients with schizophrenia. Todd and Michie et al. (2007) also reported that a clear reduction in early schizophrenia was evident in MMN to duration but not frequency deviants. By the way, we have reported that the detection sensitivity nonlinearly declines over time within TWI of 160-170-ms in sensory memory. Recently, we found that the declined sensitivity of later part was remarkable in schizophrenia. In summary, the reduced duration-MMN which was reported by Michie and Todd et al. might be caused by the dysfunction of TWI. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Review Talk Citation: Yabe H (2009). Reduced duration MMN and impaired temporal integration window in clinical populations. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Mar 2009; Published Online: 19 Mar 2009. * Correspondence: Hirooki Yabe, Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan, Japan.hyabe@fmu.ac.jp Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hirooki Yabe Google Hirooki Yabe Google Scholar Hirooki Yabe PubMed Hirooki Yabe Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.