Differential adaptation of auditory cortex neural populations as the neurophysiological basis of MMN

Abstract

Event Abstract Back to Event Differential adaptation of auditory cortex neural populations as the neurophysiological basis of MMN Iiro P. Jääskeläinen1* 1 Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Finland The mismatch negativity (MMN) auditory event-related brain potential (ERP) response is a well known correlate of perceptual and cognitive functions, allowing one to probe, for instance, auditory sensory memory, involuntary attention, sound discrimination ability, perceptual learning, as well as deficits in these functions in pathology. Here, evidence is presented suggesting that differential post-stimulus inhibition/adaptation within anterior "what" and posterior "where" auditory processing pathways gives rise to the characteristic MMN response to a change in sound frequency. Specifically, the relatively broad tuning to sound frequency of neurons within the posterior auditory cortex (and/or the standard and deviant sounds coming from the same spatial location that the posterior "where" pathway is selective to) resulted in suppression of the posterior auditory cortex response to sounds deviating from preceding standards in sound frequency. In contrast, anterior auditory cortex "what" processing pathway was suppressed less, producing a temporally lagging response, thus explaining the slightly anterior equivalent current dipole (ECD) modeled source location, longer latency, weaker amplitude, and different scalp topography for the MMN as compared with the response to the same sound presented without preceding standard stimuli. It is possible that post-stimulus inhibition of neurons selective to other sound features such as duration, spatial location, and intensity, underlie MMN responses to changes in these other sound features. In contrast to the different MMN responses recorded to changes in relatively simple stimulus features, the MMN to "abstract" sound features appears to depend on attention and thus the possible role of adaptation in eliciting (and more generally the neural basis of) the abstract-MMN response is a highly exciting challenge for future studies. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Workshop 2: The role of adaptation in deviance detection Citation: Jääskeläinen IP (2009). Differential adaptation of auditory cortex neural populations as the neurophysiological basis of MMN. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.014 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Mar 2009; Published Online: 19 Mar 2009. * Correspondence: Iiro P Jääskeläinen, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Espoo, Finland, ijaaskel@lce.hut.fi Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Iiro P Jääskeläinen Google Iiro P Jääskeläinen Google Scholar Iiro P Jääskeläinen PubMed Iiro P Jääskeläinen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.