Abstract
Genomics of model organisms
Highlights
Queen Mary, University of London, School of Biological and Chemical Sciences, Mile End Road, London E1 4NS, UK
We have taken a dual approach to mine the human genome for novel components of the global regulatory complexes that function through chromatin reorganisation
We have identified putative cis-acting elements through in silico analysis and these cis elements are validated by functional analysis in vitro and in vivo using transgenic Drosophila, as model system
Summary
Queen Mary, University of London, School of Biological and Chemical Sciences, Mile End Road, London E1 4NS, UK. The epigenetic control of gene expression through global silencers like Polycomb (PcG) and activators like Trithorax (TrxG), group of proteins which form large multiprotein complexes is functional in Drosophila and in the human genome. We have taken a dual approach to mine the human genome for novel components of the global regulatory complexes that function through chromatin reorganisation.
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