Abstract

Pharmacogenomics and toxicogenomics

Highlights

  • Epilepsy is a common, serious, and treatable neurological disorder, yet current treatment is limited by lack of complete seizure control in a significant proportion of patients

  • Taken together our results strongly suggest that TF and TR executed apoptotic cell death in A375 cells via JNK and p38 MAP kinase pathways which are triggered by NAC-sensitive intracellular oxidative stress. 351: Genotype-phenotype correlation in b-Thalassemia patients responding to hydroxyurea treatment and common b-Thalassemia mutations in the eastern Indian population

  • Our results demonstrated a significant association of single nucleotide polymorphism (SNP) for COMT before Bonferroni correction

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Summary

Pharmacogenomics and toxicogenomics

349: Evaluating the effect of genotype and haplotype frequencies of ABCB1 (MDR1) polymorphisms in medically refractory epilepsy patients of an Indian population. From these studies, we have identified a unique repertoire of genes that are overexpressed in arsenic exposed individuals with skin lesions but not in other groups. The C allele of this SNP had less expression than the A allele in reporter gene assays in RN46A cells and the C/C genotype was associated with less likelihood of response to paroxetine in depressed individuals. Reduced repair capacity caused by mutations/polymorphisms in DNA repair genes is linked to cancer predisposition, developmental abnormalities, neurological disorders, and premature aging syndromes In this direction, Nijmegen breakage syndrome 1 gene, nibrin (NBN) is employed in the present preliminary study to understand its influence and the role of its polymorphisms in DNA repair in human peripheral blood mononuclear cells. Suneetha Korivi Jyothiraj, Nirmala Nancy Karunakaran, Rajalekshmy Kamalalayam Raghavan, Rajkumar Thangarajan

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