Abstract
Klebsiella pneumoniae, an ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogen, has acquired multiple antibiotic resistance genes and is becoming a serious public health threat. Here, we report the genome sequences of two representative strains of K. pneumoniae from the emerging K. pneumoniae carbapenemase (KPC) outbreak in northeast Ohio belonging to sequence type 258 (ST258) (isolates Kb140 and Kb677, which were isolated from blood and urine, respectively). Both isolates harbor a blaKPC gene, and strain Kb140 carries blaKPC-2, while Kb677 carries blaKPC-3.
Highlights
Klebsiella pneumoniae, an ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogen, has acquired multiple antibiotic resistance genes and is becoming a serious public health threat
Klebsiella pneumoniae, a bacterium belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, K. pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), is responsible for serious community- and hospital-acquired infections [1,2,3,4,5]
The difficulty in treating infections caused by K. pneumoniae is increasing due to its ability to acquire antibiotic resistance genes [6,7,8], including carbapenemases [9]
Summary
Klebsiella pneumoniae, an ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogen, has acquired multiple antibiotic resistance genes and is becoming a serious public health threat. The difficulty in treating infections caused by K. pneumoniae is increasing due to its ability to acquire antibiotic resistance genes [6,7,8], including carbapenemases [9]. Nucleotide and whole-genome mapping comparisons among several strains led to the identification of a high heterogeneity zone (HHZ) [14], which includes the capsular polysaccharide biosynthesis gene cluster (HHZ subregion 4) and a hot spot (HHZ subregion 3), which in strain K. pneumoniae NTUH-K2044 is the point of insertion of a fragment that includes a pathogenicity island related to that found in Yersinia species.
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