Abstract
We report here the first novel HIV-1 second-generation intercirculating recombinant form 61_BC (inter-CRF61_BC), composed of two established CRFs (CRF07_BC and CRF08_BC), in China. CRF61_BC is the first CRF found among the heterosexual population in two different regions in China, suggesting the increasing significance of heterosexual transmission of HIV in China.
Highlights
We report here the first novel Human immunodeficiency virus type 1 (HIV-1) second-generation intercirculating recombinant form 61_BC, composed of two established circulating recombinant forms (CRFs) (CRF07_BC and CRF08_BC), in China
Human immunodeficiency virus type 1 (HIV-1) exhibits an extensive genetic diversity that is primarily driven by high rates of mutation, recombination, and replication
HIV-1 group M strains play a major role in the global HIV-1 epidemic and are further classified into eleven subtypes and sub-subtypes (A1, A2, B, C, D, F1, F2, G, H, J, and K), as well as a number of circulating recombinant forms (CRFs) with various unique recombinant forms (URFs)
Summary
We report here the first novel HIV-1 second-generation intercirculating recombinant form 61_BC (inter-CRF61_BC), composed of two established CRFs (CRF07_BC and CRF08_BC), in China. HIV-1 group M strains play a major role in the global HIV-1 epidemic and are further classified into eleven subtypes and sub-subtypes (A1, A2, B, C, D, F1, F2, G, H, J, and K), as well as a number of circulating recombinant forms (CRFs) with various unique recombinant forms (URFs). 58 CRFs have been reported in the Los Alamos National Laboratory HIV database (http://www.hiv.lanl .gov/content/sequence/HIV/CRFs/CRFs.html).
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