Abstract
Lawsonia intracellularis is the etiological agent of proliferative enteropathy (PE), causing mild or acute hemorrhagic diarrhea in infected animals. Here we report the genome sequence of strain N343, isolated from a sow that died of hemorrhagic PE. N343 contains 24 single nucleotide polymorphisms and 90 indels compared to the reference strain PHE/MN1-00.
Highlights
L. intracellularis N343 was propagated in Int407 cells at 37°C under microaerophilic conditions (8.8% CO2, 8.0% O2) (3)
We report the genome sequence of L. intracellularis N343, which was isolated from the ileum of a sow from a farm in Minnesota that died of hemorrhagic proliferative enteropathy (PE)
L. intracellularis N343 is composed of a 1,457,568-bp circular chromosome with a GϩC content of 33.2%, with 1,182 predicted coding sequences (CDSs)
Summary
L. intracellularis N343 was propagated in Int407 cells at 37°C under microaerophilic conditions (8.8% CO2, 8.0% O2) (3). Lawsonia intracellularis is a Gram-negative, obligate intracellular bacterium which has been identified as the causative agent of proliferative enteropathy (PE). It was shown that host susceptibility to L. intracellularis infection depended on the species of origin (2), highlighting the need for additional genome sequences to facilitate our understanding of the mechanisms of infection and pathogenesis. We report the genome sequence of L. intracellularis N343, which was isolated from the ileum of a sow from a farm in Minnesota that died of hemorrhagic PE.
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