Abstract
ABSTRACTCaseous lymphadenitis (CLA) is an acute, pyogenic, and contagious disease of goat that imposes considerable economic losses for farmers, and it is caused by Corynebacterium pseudotuberculosis. Herein, we introduce the genome sequencing of C. pseudotuberculosis strain KM01, isolated from an abscess of a Saanen goat from Kunming, China. The genome contains 2,198 genes, the total length of the genes was 2,337,666 bp, and the GC content was 52.18%. The number of tandem repeat sequences was 44, the total length of the tandem repeat sequences was 1,970 bp (0.0772% of the genome), the number of minisatellite DNAs was 36, and there were 48 tRNAs and 12 rRNAs.
Highlights
Caseous lymphadenitis (CLA) is an acute, pyogenic, and contagious disease of goat that imposes considerable economic losses for farmers, and it is caused by Corynebacterium pseudotuberculosis
To better understand and enrich the genomic information of a C. pseudotuberculosis isolate from Kunming, China, we sequenced the genome of C. pseudotuberculosis strain KM01
Controlling CLA with highly sensitive antibiotics was a total failure, since viable bacteria stay in protected inside abscesses due to the thick capsule that surrounds them
Summary
Caseous lymphadenitis (CLA) is an acute, pyogenic, and contagious disease of goat that imposes considerable economic losses for farmers, and it is caused by Corynebacterium pseudotuberculosis. To better understand and enrich the genomic information of a C. pseudotuberculosis isolate from Kunming, China, we sequenced the genome of C. pseudotuberculosis strain KM01. It was originally isolated in Kunming, China, from an abscess in the neck of a 2-year-old Saanen goat in March 2017. A drug sensitivity test showed KM01 to be sensitive to 27 of total 34 antibacterial agents, including cefotaxime, gentamicin, florfenicol, ofloxacin, tetracycline, levofloxacin, azithromycin, ciprofloxacin, acetylspiramycin, erythromycin, chloramphenicol, roxithromycin, sulbactam, enrofloxacin, ampicillin, vancomycin, ticarcillin, penicillin, rifampicin, albamycin, cephradine, cephalothin, lincomycin, amikacin, kanamycin, cephalexin, and clindamycin, but it was completely resistant to sulfamethoxazole-trimethoprim (SMZ-TMP), metronidazole, streptomycin, polymyxin, bacitracin, trimethoprim, and amoxicillin.
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