Abstract
A complex HIV-1 unique recombinant form involving subtypes CRF01_AE, B, and B′ was recently identified from an injecting drug user in Malaysia. A total of 13 recombination breakpoints were mapped across the near-full-length genome of isolate 10MYPR226, indicating the increasingly diverse molecular epidemiology and frequent linkage among various high-risk groups.
Highlights
A complex Human immunodeficiency virus type 1 (HIV-1) unique recombinant form involving subtypes CRF01_AE, B, and B= was recently identified from an injecting drug user in Malaysia
HIV-1 group M consists of nine subtypes (A to D, F to H, J, and K) and recently, 61 circulating recombinant forms (CRFs)
In Asia, the wide cocirculation and dual infection of CRF01_AE and subtypes B of western origin and B= of Thai origin that were primarily associated with the epidemics among heterosexuals, men who have sex with men (MSM), and people who inject drugs, respectively, may play an important role in the emergence of diverse intergenotype recombinants
Summary
A complex HIV-1 unique recombinant form involving subtypes CRF01_AE, B, and B= was recently identified from an injecting drug user in Malaysia. Human immunodeficiency virus type 1 (HIV-1) is characterized by extensive genetic diversity due to the error-prone reverse transcriptase, high viral turnover rates, and genetic recombination (1). HIV-1 group M consists of nine subtypes (A to D, F to H, J, and K) and recently, 61 circulating recombinant forms (CRFs) (http://www.hiv.lanl.gov).
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