Abstract
Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii. Little is known about the genetic characteristics of clinical strains of Acinetobacter baumannii lacking the AdeABC pump. In this study, we sequenced the genome of clinical strain Ab421 GEIH-2010 (belonging to clone ST79/PFGE-HUI-1 from the GEIH-REIPI Ab. 2010 project) which lacks this efflux pump.
Highlights
Acinetobacter baumannii is an important pathogen that causes nosocomial infections associated with high morbidity and mortality [1]
Three resistance-nodulation-cell division-type efflux pumps have been described in the A. baumannii clinical strains AdeABC, AdeIJK, and AdeFGH
The AdeABC efflux pump confers high-level resistance to several antibiotics and is regulated by the two-component AdeRS system [2, 3]
Summary
Acinetobacter baumannii is an important pathogen that causes nosocomial infections associated with high morbidity and mortality [1]. Three resistance-nodulation-cell division-type efflux pumps have been described in the A. baumannii clinical strains AdeABC, AdeIJK, and AdeFGH. The AdeABC efflux pump confers high-level resistance to several antibiotics and is regulated by the two-component AdeRS system [2, 3]. A type of TetR-type transcriptional regulator (AdeN) has been associated with overexpression of the AdeIJK efflux pump involved in resistance to several antimicrobials [4].
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