Abstract
ABSTRACTAn H4N6 subtype avian influenza virus was isolated from a pockmark duck in southern China in November 2013 and named A/duck/Guangxi/149D24/2013 (H4N6). All eight gene segments of the strain were sequenced. Sequence analysis indicated that this H4N6 virus was a natural reassortant virus. This H4N6 virus has two basic amino acids in the cleavage site of hemagglutinin 1 (HA1) and HA2, and the amino acid motif of cleavage site was PEKASRGLF, which is the typical characteristic of the low-pathogenic avian influenza virus. This study will help understand the epidemiology and molecular characteristics of avian influenza virus in pockmark ducks.
Highlights
An H4N6 subtype avian influenza virus was isolated from a pockmark duck in southern China in November 2013 and named A/duck/Guangxi/149D24/ 2013 (H4N6)
This H4 subtype of Avian influenza virus (AIV) belongs to low-pathogenic AIV (LPAIV), which is one of the predominant subtypes among LPAIV
The complete genome of the A/duck/Guangxi/149D24/2013 (H4N6) strain consists of eight gene segments of polymerase basic 2 (PB2), PB1, polymerase acidic (PA), HA, nucleoprotein (NP), NA, matrix (M), and nonstructural (NS) genes
Summary
An H4N6 subtype avian influenza virus was isolated from a pockmark duck in southern China in November 2013 and named A/duck/Guangxi/149D24/ 2013 (H4N6). The H4 subtype of AIV has been circulating and evolving in live poultry markets in China [5]. It has been shown that the H4 subtype of AIV has infected migratory water birds and domestic ducks [6, 7]. The H4 subtype of AIV has infected pigs and poses a threat to mammals [8].
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