Abstract
THE SIMILARITY of the chemical formulae of the two stilbenes, (4,4′-stilbenedicarboxamidine) and diethylstilbesteol (4,4′dihydroxy-α,α′-diethylstilbene) was pointed out in previous papers*and their in vitro and in vivo activity against various pathogenic fungi was demonstrated. Stilbamidine has been used clinically in the treatment of North American blastomycosis with favorable results, but at the same time it has exhibited certain objectionable toxic properties, especially trigeminal neuropathy, and, with the present methods of administration and dosage schedules, post-therapeutic recurrences are not too uncommon.3The in vitro anti-fungal activity of diethylstilbestrol is greater than that of stilbamidine, but its clinical trials in the mycoses are not as extensive as those of stilbamidine. A definite deterrent to its use is its well-known potency as a hormone. These shortcomings led to further studies of the antifungal activity of other members of the stilbene group as well as related compounds, in the
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