FUNCTIONAL CHANGES IN EXTRA-EMBRIONAL BLOOD FLOW DURING THE FORMATION OF THE PLACENTAL COMPLEX ON THE BACKGROUND OF INFLAMMATORY DISEASES OF THE FEMALE GENERAL ORGANS

Abstract

The introduc tion of diagnostic ultrasonography into clinical medicine has given a powerful impetus to the development of practical obstetrics. The use of ultrasound methods of research makes it possible to widely use the possibilities of a comprehensive morphological and functional assessment of the embryo, chorion, extraembryonic structures, and not only to state the already existing pathology, but also in most cases to make judgments about the pathogenetic mechanisms that led to the development of pathological conditions. One of the main complications in early embryogenesis and placentation is placental dysfunction. Under the infl uence of various factors, namely infectious, depending on the biological specifi city, they negatively aff ect the germ cells of the parents, the development of the embryo, the formation of the trophoblast and placenta, which in turn leads to impaired function of the placental complex and gestational complications during pregnancy.Due to the expansion of diagnostic capabilities for detecting placental dysfunctions, as well as in connection with the emergence of new data on the mechanisms of regulation of blood circulation in the placenta, we determined the Dopplerometric picture of blood fl ow features (ovarian artery, intervillous space) in women of the main and control groups.According to the goal, an ultrasound examination was performed on 67 women at 6-7 and 12-14 weeks of gestation. The main group consisted of 37 women with signs of infl ammatory diseases of the female genital organs, the control group consisted of 30 women who were practically healthy.Obtaining new data on the mechanisms of regulation of blood circulation in the ovarian artery and intervillous space at the stage of formation of the placental complex during physiological and complicated pregnancy will complement the pathogenesis of the development and prevention of placental dysfunction.