Частота дефицита кальцитриола и полиморфизма гена рецепторов витамина D у беременных с плацентарной дисфункцией на фоне перинатального инфицирования

Abstract

The pleiotropic extra-skeletal effects of calcitrioland its effect on the development of pregnancies various complications are now devoted to many researches. The objective: to evaluate the vitamin D status and frequency of polymorphism of the VD receptor’s (VDR) gene in pregnant women with placental dysfunction (PD) and verified perinatal infection (VPI). Materials and methods. There were 40 patients with a physiological pregnancy and 56 pregnant women with PD on the VPI background examined. The level of total VD in serum was determined by immunoassay; by polymerase chain reaction were assessed the frequency of the BsmI-polymorphism (A> G, rs1544410) of the VDR gene. Results. In patients with PD, a vitamin D-deficiency status is diagnosed more frequently – 28.5% VS 15.30% (RR=1.42; 95%CI: 1.08–1.87; р≤0.05). The level of VD in serum of women with PD is lower than in women with a physiological pregnancy (31.40±8.6 ng/ml VS 43.54±11.20 ng/ml, p≤0.01). In women with PD (71.43%), the heterozygous combination of A / G-type alleles was identified more often than in healthy pregnant women (35%) (OR=3.61; 95%СІ: 2.01–6.47; χ2 19.24; р<0.01): in carriers of this type of Bsml-polymorphism of the VDR gene, the risk of PD increases 3.6-fold. Conclusions. The formation of PD of the pleiotropic effects of vitamin D саn be explained particularly, but further research is necessary, including in the molecular genetic direction, which are likely to help in preventing the development of placental dysfunction in a some group of women. Key words: vitamin D, calcitriol, receptors, pregnancy, placental dysfunction, gene polymorphism.