Abstract
Cronobacter is associated with infant infections and the consumption of reconstituted infant formula. Here we sequenced and closed six genomes of C. condimentiT, C. muytjensiiT, C. universalisT, C. malonaticusT, C. dublinensisT, and C. sakazakii that can be used as reference genomes in single nucleotide polymorphism (SNP)-based next-generation sequencing (NGS) analysis for source tracking investigations.
Highlights
Cronobacter is a foodborne pathogen that has been identified as the causative agent of severe clinical complications in neonates and infants, such as meningitis, necrotizing enterocolitis, and septicemia [1, 2]
The origin of this pathogen is not clear, but Cronobacter has been isolated from a wide range of foods, among which powdered infant formula (PIF) has been identified as the dominant vehicle of transmission [3, 4]
The clustering and the creation of phylogenic trees based on single nucleotide polymorphism (SNP) analysis of the next-generation sequencing (NGS) data are carried out by mapping short read sequences of Cronobacter isolates to a reference genome
Summary
Cronobacter (formerly Enterobacter sakazakii) is a foodborne pathogen that has been identified as the causative agent of severe clinical complications in neonates and infants, such as meningitis, necrotizing enterocolitis, and septicemia [1, 2]. The origin of this pathogen is not clear, but Cronobacter has been isolated from a wide range of foods, among which powdered infant formula (PIF) has been identified as the dominant vehicle of transmission [3, 4]. Cronobacter is often isolated from the environment and can be found in soil samples, domestic kitchens, and predominantly PIF manufacturing facilities [5, 6].
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