Fréquence de la fixation physiologique de l’uncus pancréatique en scintigraphie à l’111In-pentétréotide : étude rétrospective chez 198 patients

Abstract

AimThe aim of this study is to evaluate the frequency of physiological 111In-DTPA-octreotide uptake in the pancreatic uncinate process, on SPECT-CT acquisitions. MethodsWe analysed retrospectively 247 patients 111In-DTPA-octreotide SPECT-CT images realized in the nuclear medicine department of Haut-Lévêque hospital (CHU of Bordeaux, France) between June 2012 and March 2015. Intensity uptake of pancreas uncinate process was classified in comparison with physiological liver and spleen uptake. When positive, an uptake was considerated as physiologic when radiological investigations (CT, MRI or echoendoscopy) did not show anatomical lesion in the pancreatic head, or if no lesion appeared during clinical and radiological follow-ups. ResultsOne hundred and ninety-eight patients without uncus and cephalic pancreatic lesion were analysed. Forty-two percent had a physiological 111In-DTPA-octreotide uptake in the pancreatic uncinate process. Uptake intensity was significant (greater than or equal to liver uptake) in 17%. ConclusionIntense physiological 111In-DTPA-octreotide uptake of the pancreatic uncinate process can occur in 17% of cases on SPECT-CT acquisitions. This tracer accumulation can mimic malignancy in pancreatic head. Uptake in the pancreatic uncinate process should be correlated with morphologic examinations, such as CT, MRI or somatostatin PET-CT if available.