Abstract
Objective – before and after the treatment to determine the functional state of the liver, serum levels of enzymes and biochemical indices in syphilis patients with viral hepatites B and C. The results of the study are based on the data from a comprehensive examination of 35 patients with syphilis alone and 127 patients with syphilis co-infected with viral hepatites B and C before and after treatment. Test methods: hepatology, rheogeopathography, enzyme content and biochemical parameters determined in the serum. According to the results of radionuclide hepatology it has been established that disorders of the functional capacity of the liver already occur in the early stages of the disease. The most significant disorders have been in the patients with the prescription of infection for more than 12 months and in the patients co-infected with viral hepatites B and C. A disorder of pigment metabolism and increased activity of transaminases have been revealed in early latent syphilis. In co-infection with viral hepatites B and C an increase in total bilirubin, Lactate dehydrogenase, Alanine transaminase, Aspartate aminotransferase and albumin has been revealed. Dysproteinemia has been revealed in patients with early latent syphilis co-infected with hepatitis C. Patients with early latent syphilis treated with immunomodulators tend to normalize these indices. In patients with syphilis a disorder of the functional state of the liver have been revealed already at an early stage of the disease. The most pronounced disorder of biochemical parameters and activity of liver enzymes are observed in syphilis patients with viral hepatites B and C, as well as in patients with early latent syphilis only with the prescription of the infection for more than 12 months; in such a case it is advisable to use drugs affecting the immune system.
Highlights
We have examined: - 30 healthy persons; - 35 patients with the infectious forms of syphilis only; - 127 patients with contagious forms of syphilis coinfected with viral hepatites, divided into three groups: 1) group 1 – patients with syphilis co-infected with viral hepatitis B (59 persons); 2) group 2 – patients with syphilis co-infected with viral hepatitis C (25 persons); 3) group 3 – patients with syphilis co-infected with viral hepatites B and C (43 persons)
The patients with syphilis co-infected with viral hepatitis B tended to decrease in the amplitude β; those patients revealed a statistically significant decrease of mean values of Tβ and elevated Q
Substantial changes in individual rheogram parameters were observed in syphilis patients with viral hepatitis C and especially in patients with secondary and early latent syphilis which were characterized by:
Summary
Особливості біохімічних показників і вмісту ферментів у сироватці крові хворих на сифіліс, коінфікованих вірусними гепатитами В і С у процесі лікування. Мета роботи – до та після лікування визначити функціональний стан печінки та вміст у сироватці крові ферментів і біохімічних показників у хворих на сифіліс, ко-інфікованих вірусними гепатитами В і С. Найбільш суттєві порушення були у хворих з давністю інфекції більше 12 місяців і в пацієнтів, ко-інфікованих вірусними гепатитами В і С. У хворих на сифіліс уже на ранніх стадіях захворювання спостерігається порушення функціонального стану печінки. CLINICAL MEDICINE біохімічних показників та активності ферментів печінки спостерігаються у хворих на сифіліс, ко-інфікованих вірусними гепатитами В і С, а також у хворих тільки на ранній прихований сифіліс з давністю зараження більше 12 місяців; у такому випадку доцільно використовувати препарати, що впливають на імунну систему. Since the mid-1990s, the number of cases of viral hepatites B and C associated with the injection drug addiction and sexually transmitted diseases has increased significantly [15]
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