Abstract
Purpura simplex is a term applied to mild spontaneous purpuric skin manifestations with no hematological abnormality and with the Rumpel-Leede phenomenon frequently present. The condition occurs almost only in women, rarely in children, and is often familial. It has been well recognized since the descriptions by Willan and Bateman early in the 19th century. The hereditary feature was first noted by Bauer in 1868. Davis gave the name hereditary familial purpura simplex to this syndrome, which occurred in 88 members of 27 families studied in London. Soulier in France confirmed Davis' findings and noted bleeding in mucous membranes as well as in the skin. In five of Davis' families a case of Schonlein-Henoch purpura was noted. In Bauer's family study, reported in 1868, one of three sisters having purpura simplex developed severe visceral hemorrhages and died at 22 years of age (perhaps of Henoch's purpura). Schonlein-Henoch syndrome is the term
Published Version
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