Changes and significance of serum interleukin-17 and matrix metalloproteinase-9 in children of henoch-schonlein purpura

Abstract

Objective To investigate the chanegs and correla iton between IL-17 and MMP-9 in c hildren of henoch-schonlein purpura,and to explore the pathogenesis of teh IL-17 and MMP-9 in henoch-schonlein pur-pura /henoch-schonlein purpura nephritis.Methods The level of serum IL-17 andMMP-9 in 74 henoch-schon-lein purpura childr en in initial stage and 30 cases of healthy children（ control group） were detetced by ELISA. Results （1） The level of plasma IL-17 was significantly higher in children of henoch-schonlein purpura thna tha t foh ealthy control group （86.59 ±35.50） fg/L vs.（62.38 ±14.65）fg/L,P〈0.01].（2） The level of plasma MMP-9 was significantly higher in children of henoch-schonlein pupru ar than that o fhealt hy control group [（201.82 ±105.87） fg/L vs（89.27 ±27.99）fg/L,P 〈0.01].（3） Henoch-schonlein purpura children were followed up for6 months,dependin g on whether the kidney was involved,they were devided into non-henoch-schonlein purpura nephritsi grou p nad henoch-s chonlein purpura nephritis group.In initial phase of HSP,the level of plasma IL-17 was significant lyhigher in henoch-schonlein purpura nephritis group than non-henoch-schonlein purpura nephrits group [（101.67 ±39.55） fg/L vs.（101.67 ±39.55）fg/L,P〈0.05].The level of p lasma MMP-9 was significantly higher in henoch-schonlein purpura nephritsi group than no n-henoc h-schonlein purpura nephritis group [（249.63 ±97.57） Pg/L vs.（185.30 ±104.39） pg/L,P〈0.05 ].（4） IL-17 and MMP-9 correlation aanlysis didn＇t show sign ificant correlation（r=0.184,P〉0.05）.Conclusion IL -17 and MMP-9 are involved in the pathogenesis of henohc-schonlein purpura/henoch-schonlein pur pura nephritis. Key words: Henoch-Schonlein purpura; Interleukin-17; Matrix metalloproteinase-9