Changes in plasma factor XIII-A subunit in children with Henoch-Schönlein purpura and its clinical significance

Abstract

Objective To explore the correlation between changes in plasma factor ⅩⅢ-A subunit(FⅩⅢ-A) levels in children with Henoch-Schonlein purpura(HSP) during active stage and involvement important organs, and other coagulation fibrinolytic dysfunction, and to provide theoretical basis for effective treatment. Methods A total of 117 children hospitalized with HSP from Nov. 2012 to Mar. 2013 in the First Affiliated Hospital of Anhui Medical University were divided into 3 groups: general HSP group(59 cases), gastrointestinal bleeding HSP group(21 cases), and HSP nephritis(HSPN) group(37 cases). Twenty-three healthy children were included as healthy control group. The plasma FⅩⅢ-A levels of the 117 patients with HSP during active stage and 21 HSP sufferers with gastrointestinal bleeding during recovery stage were detected by using enzyme-linked immunosorbent assay. Fully automatic hematology analyzer and fully automatic blood coagulation analyzer were used to detect blood leukocytes and other coagulation fibrinolytic indexes. Results 1. The levels of plasma FⅩⅢ-A in gastrointestinal bleeding HSP group were significant lower than those in other groups(P 0.05).2. The levels of Fibrin(o)gen degradation products(FDP), D-dimer, fibrinogen, WBC, PLT and platelet hematocrit in general HSP group, gastrointestinal bleeding HSP group and HSPN group were significant higher than those of healthy control group(all P<0.05). The levels of FDP and D-dimer in gastrointestinal bleeding HSP group and HSPN group were significant higher than general HSP group(P<0.01). The levels of FDP and D-dimer in gastrointestinal bleeding HSP group were significantly higher than those of the HSPN group (P<0.05).3. There was a significant negative correlation between FⅩⅢ-A and 24 h urinary protein excretion in HSPN group(P<0.05). Conclusions The levels of plasma FⅩⅢ-A were correlated well with the severity of gastrointestinal bleeding and renal involvement in children with HSP, and anticoagulant therapy should be performed according to clinical types and in the different stages. Key words: Factor ⅩⅢ-A subunit; Henoch-Schonlein purpura; Nephritis; Child