Abstract
Objective To study the expression and prognostic value of Sonic hedgehog (Shh) and the downstream transcriptional factor Cli1 in Shh signal pathway in gastric cancer. Methods 100 primary gastric cancer samples and 10 normal gastric mucosa samples were selected in histopathological tissue bank of 1st affiliated hospital of Sun Yat-sen University. The expression of Shh and Gli1 was detected by using immunochemistry staining. Results Shh and Cli1 staining was positive in all gastric cancer samples,while only three samples were positive in normal gastric mucosa ( 3/10, 30% ) , and the staining intensity was lower in normal tissues than in cancer samples (P＜0. 01). Shh and Gli1 were associated with worse differentiation, metastasis, late stage and shorter survival. Shh and Gli1 showed linear positive correlation in gastric cancer with a correlation coefficient equal to 0. 747 ( P ＜ 0. 01 ). The survival was shortened along with the increases in Shh and Gli1 staining intensity (P＜0. 05). Conclusion Shh signal pathway played an important role in gastric carcinogenesis, and Shh and Gli1 overexpression was associated with worse prognosis. Key words: Gastric carcinoma; Sonic hedgehog; Prognosis
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