Abstract
Objective To investigate the expression of sonic hedgehog(SHH) and its clinical significance in human pancreatic cancer(hPC). Methods RT-PCR and immunohistochemistry were used to determine the mRNA and protein expression of SHH in hPC tissue and normal tissues adjacent to the cancer. Results The SHH mRNA expression was detected in 78. 9%(30/38) of the samples of pancreatic cancer, while in only 18. 4%(7/38) of those of normal tissues adjacent to the cancer. Immunohistochemical analysis showed that the SH H protein expression rate was 84.2%(32/38) in pancreatic cancer tissue and 21.1%(8/38) in normal tissues. There was significant difference between them(P 0. 05). Conclusion The expression level of SHH signal molecule is increased in hPC. The overexpression of SHH signaling pathway might play an important role in carcinogenesis and development of pancreatic cancer. Key words: Pancreatic neoplasms; Tumor; Sonic hedgehog
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