Expression and clinical significance of uPA and Cath-D proteins in the diagnosis of cervix carcinoma and cervical intraepithelial neoplasia

Abstract

Objective To investigate the expression,and biological significance of uPA and Cath-D in early diagnosis of cervix carcinoma and cervical intraepithelial neoplasia.Methods The immunohistochemical SP was used to detect the expression of uPA and Cath-D proteins in 39 CA.ges with cervix carcinoma and 33 ofpatients with CIN cases and 15 cases with normal cervical epithelia.Results Positive rates of uPA and Cath-D in the cervix carcinoma were significantly higher than in the CIN.Positive rates of uPA and Cath-D in the CIN and the cervix carcinoma were significantly higher than in the normal cervical epithelia. The difference had statistical significance( P＜0. 05 ). In the group of CIN Ⅰ/CIN Ⅱ/CINⅢ ,the expression of uPA and Cath-D had significant diffcrence(P ＜0. 05). In the group of highly, moderate and lowly developed tissue, the expression of uPA and Cath-D had significant difference (P＜0. 05). In the group with and without LNM, the expression of uPA and Cath-D had significant difference( P＜0. 01 ).Conclusions uPA and Cath-D may involve in the initiation of CIN, cervix carcinoma, uPA and Cath-D could be used as markers for early diagnosis of cervix carcinoma. It could be helpful for increasing the ratio of earlier diagnosis in the fields of cervix carcinoma. Key words: Cervical intraepithelial neopiasia; Cervical neoplasm; Urokinase-type plasminogen activator; Cathepsin D; Immunohistochemistry