Study of the Expression of p53,MDM2 Protein in Cervical Intra-epithelial Neoplasm and Cervical Squamous-cell Carcinoma

Abstract

Objective To study the roles of MDM2 and p53 protein playing in the pathogenesis and development of cervical carcinoma.Methods The expression of MDM2 and p53 protein in normal cervical epithelium,cervical intra-epithelial neoplasm(CIN) and invasive cervical squamous-cell carcinoma(SCC) were detected with immunohistochemical SP methods in 76 cases.Results 1.The expression rates of MDM2 and p53 were gradually increased with cervical lessions progress.The positive rates of MDM2 and p53 in normal cervical epithelium,CIN and invasive carcinoma were,0,13.64%,44.12%;5.00%,18.18%,47.06%;respectively.The positive rates of MDM2 and p53 in invasive cervical carcinoma group were obviously highier than those of normal cervical epithelium group and CIN group.2.The frequence of MDM2 did not show correlation with accumulation of p53 in statistics. Conclusion MDM2 and p53 may be involved in the pathogenesis and development in cervical carcinoma,and be valualble in diagnosis and treatment in cervical carcinoma.