Abstract
Background: Medicinal plants are considered a rich source of ingredients, which can be used in drug development and synthesis. Tinospora cordifolia (Wild.) Hook.f. & Thomson, commonly known as guduchi, heart-leaved moonseed and giloya is a herbaceous vine of the family Menispermaceae, has several beneficial properties including antioxidant activity. Aim: The present study was carried out to analyze the antioxidant activity of leaf and stem extracts of Tinospora cordifolia by using DPPH (1,1-Diphenyl-2-picrylhydrazyl) and ABTS (2,2´-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) free radical scavenging assays. Materials and Methods: Dried and powdered leaves and stem of T. cordifolia were extracted with methanol. Ascorbic acid was taken as standard. Total phenolic content was estimated by using Folin-ciocalteu's reagent while total flavonoid content by aluminium chloride reagent to find the correlation of polyphenols with antioxidant activity. ABTS assay of methanolic leaf and stem extracts showed the highest scavenging activity as compared to the DPPH assay. Results: Methanolic stem extract showed higher phenolic and flavonoid content along with antioxidant activity as compared to the methanolic leaf extract. Conclusion: The stem extract exhibited more antioxidant activity than the leaf extract with regards to the all parameters analyzed.
Highlights
Plants are one of the most important sources of medicines
The plant material (Tinospora cordifolia (Wild.) Hook.f. & Thomson) of the present study was collected from Haldwani, District Nainital, Uttarakhand, India (Latitude: 29.17558; Longitude: 79.51718; Altitude: 424m)
Similar results were observed by Upadhyay et al [14] in the methanolic stem extract of T. cordifolia and found that at a concentration of 10 mg/mL, DPPH free radical scavenging activity was low (44%)
Summary
Plants are one of the most important sources of medicines. They can synthesize different bioactive molecules such as phenols, flavonoids, vitamins, alkaloids, terpenoids, tannins, glycosides, quinones and many others. Medicinal plants are considered a rich source of ingredients, which can be used in drug development and synthesis. & Thomson, commonly known as guduchi, heart-leaved moonseed and giloya is a herbaceous vine of the family Menispermaceae, has several beneficial properties including antioxidant activity Tinospora cordifolia (Wild.) Hook.f. & Thomson, commonly known as guduchi, heart-leaved moonseed and giloya is a herbaceous vine of the family Menispermaceae, has several beneficial properties including antioxidant activity
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