Abstract
The effect of Sargassum pallidum (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with Sargassum pallidum aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10) levels, decreasing interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that Sargassum pallidum aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats.
Highlights
Gastric cancer is the second commonest cause of death from malignant disease worldwide [1].Antioxidant compounds, such as vitamin C and vitamin E, play a key role in the prevention and termination of development of gastric cancer [2]
We investigated the effect of Sargassum pallidum aqueous extract on the immunity functions and antioxidant activities in gastric cancer rats
Sargassum pallidum aqueous extract led to significant suppression of serum IL-6, TNF-α levels, and significant enhancement of serum IL-2, IL-4, IL-10 levels in this model
Summary
Gastric cancer is the second commonest cause of death from malignant disease worldwide [1]. Antioxidant compounds, such as vitamin C and vitamin E, play a key role in the prevention and termination of development of gastric cancer [2]. Molecules 2012, 17 nowadays due to the unpredictable side effects of the long-term use of commercially available drugs. As it affects 5% of the global population [3], the treatment of this painful disease and its prevention has become one of the challenging medical problems of the day. We investigated the effect of Sargassum pallidum aqueous extract on the immunity functions and antioxidant activities in gastric cancer rats
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call