Abstract
Background: Myasthenia gravis (MG) is an autoimmune disease that leads to fatigue and weakness after voluntary activities. If early diagnosed, MG can be treated, and a person’s performance and quality of life can be greatly improved as well. Materials and Methods: The study population of the present cross-sectional study included 80 patients with MG referring to Sina (Farshchian) hospital in Hamadan, Iran. The inclusion criterion included complete medical files. Finally, the variables were investigated using the chi-square test and two-sample t test by SPSS, version 16. Results: The mean (standard deviation) of the patients’ age was 45.6 ± 15.8 years and most patients (55.5%) were females and 72.5% of them were married. In addition, weakness, lethargy, and premature fatigue were the most common symptoms (47.5%) in patients while unsteady gait was the lowest prevalent symptom (11.3%). There was no significant relationship between gender and the incidence of symptoms in patients (P>0.05). However, a significant relationship was found between patients’ age with the shortness of breath and unsteady gait (P<0.05). Eventually, most women, especially married and elderly ones, contracted the disease. Conclusion: In general, there is a proper treatment for MG considering its early diagnosis. Accordingly, it is recommended that the level of awareness should be increased about the disease and provide appropriate medical and therapeutic facilities in this regard.
Highlights
Myasthenia gravis (MG), which manifests as muscle weakness, is caused by a neuromuscular disorder [1]
MG, which is a neurological type of muscle paralysis, is an autoimmune disease occurring at the neuromuscular junction and is often caused by an anti-acetylcholine receptor antibody [5,6,7,8]
MG is due to an autoimmune attack on the components of the postsynaptic muscle membrane, which is an antibody against muscle nicotinic acetylcholine receptors in most patients [11]
Summary
Myasthenia gravis (MG), which manifests as muscle weakness, is caused by a neuromuscular disorder [1]. MG is due to an autoimmune attack on the components of the postsynaptic muscle membrane, which is an antibody against muscle nicotinic acetylcholine receptors in most patients [11] This process causes a kind of muscle weakness following voluntary activities and is exacerbated by physical activity while it is improved by rest [12]. Voice change, and respiratory distress [15], bulbar weakness, and dysphagia and dysarthria [16] Both males and females may contract MG in any age group, but recent studies have shown that its peak in women is in the second and third decades of life while the peak in men is in the fifth and sixth decades.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
