Abstract
The antibacterial activity of local Sidr and Mountain Saudi honeys against Escherichia coli,Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii were evaluated. Disc diffusion method, gel diffusion method, minimum inhibitory concentration (MIC)and minimum bactericidal concentration (MBC) values were used in this investigation. The findings indicated that both honey samples had growth inhibitory effect and all tested gram negative bacteria were sensitive to 40-80% concentrations. Increasing the honey concentration significantly (P≤0.05) increased the inhibition of growth of the tested bacteria. Sidr honey was more potent than Mountain honey in producing the inhibitory growth effect as an antibacterial agent. Sidr and Mountain honeys in different concentrations were more effective against E.colithan other bacteria. MIC of the two honey samples was 20 mg/mL while the MIC of K. pneumoniae was 40 mg/mL in the case of Mountain honey. The MBC of the two honey samples was 40 mg/mL and the MBC of A. baumannii that valued was 20 mg/mL. We are of the opinion that Sidr and Mountain Saudi honeys could potentially be used as therapeutic agents against bacterial infection particularly to the tested microorganisms. Key words: Saudi honey, Sidr honey, mountain honey, Gram negative, antibacterial agents
Highlights
Antimicrobial agents are essentially important in reducing the global burden of infectious diseases
Sidr honey is made from bees who feed only on the nectar of the Sidr tree, which is native to the South Saudi Arabia and Yemen regions
Isolates of E. coli, K. pneumoniae, P. aeruginosa and A. baumannii strains were obtained from the department of microbiology at the King Khalid Hospital (KKH) of Najran city, Saudi Arabia
Summary
Antimicrobial agents are essentially important in reducing the global burden of infectious diseases. As resistant pathogens develop and spread, the effectiveness of the antibiotics is diminished. This type of bacterial resistance to the antimicrobial agents poses a very serious threat to public health and all kinds of antibiotics, including the major last-resort drugs, as the frequencies of resistance are increased worldwide (Levy and Marshall, 2004; Mandal et al, 2009). There are many reports of bactericidal as well as bacteriostatic activity of honey and the antibacterial properties of honey may be useful against bacteria, which have developed resistance to many antibiotics (Patton et al, 2006). Sidr honey is a "monofloral honey", a type of honey which has a high value in the marketplace because it has a distinctive flavor or other attribute due to its being
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