Electron Microscopy of Cells Infected with Adenovirus Type 12

Abstract

The presence of non-viral paracrystalline protein in cells infected with adenovirus type 5 (2) and adenovirus type 2 (4) has been reported.The present studies revealed adenovirus type 12 produced: (a) paracrystalline bodies in KB cells morphologically similar to that induced by adenovirus type 5 and (b) small crystalline lattices which consisted of tubular subunits.The sequential developmental studies of adenovirus type 12 were made in KB cells and in cell lines derived from human origin. In the infected KB cells, the intranuclear patches and stipplings were clearly seen beginning at 18th hour of inoculation (Fig. 1).