Eight Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. caucasica Isolated from the Common Vole (Microtus arvalis) Plague Focus in Dagestan, Russia.

Angelina A Kislichkina,Nadezhda V Maiskaya,Svetlana V Dentovskaya,Andrey P Anisimov,Mikhail E Platonov,Aleksandr G Bogun,Viktor I Solomentsev,Lidiya A Kadnikova

doi:10.1128/genomea.00847-17

Angelina A Kislichkina, Nadezhda V Maiskaya + Show 6 more

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https://doi.org/10.1128/genomea.00847-17

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Abstract

ABSTRACTWe here report the draft genome sequences of 8 Yersinia pestis subsp. microtus bv. caucasica strains isolated from the East Caucasian (previous name, Dagestan) mountain focus (no. 39), representing the most ancient branch of the 0.PE2 phylogroup circulating in populations of common voles (Microtus arvalis).

Highlights

We here report the draft genome sequences of 8 Yersinia pestis subsp. microtus bv. caucasica strains isolated from the East Caucasian mountain focus, representing the most ancient branch of the 0.PE2 phylogroup circulating in populations of common voles (Microtus arvalis)
The data of 25-locus multiple-locus variable-number tandem-repeat analysis (MLVA25) typing of Y. pestis subsp. microtus bv. caucasica strains (3) suggest that the strains from the East Caucasian mountain focus represent the most ancient branch of the 0.PE2 phylogroup circulating in populations of common voles (Microtus arvalis)
Only one whole-genome sequence of the strains from this ancient plague focus, which is characterized by a polymorphism of circulating their strains, has been deposited in GenBank

Summary

Introduction

We here report the draft genome sequences of 8 Yersinia pestis subsp. microtus bv. caucasica strains isolated from the East Caucasian (previous name, Dagestan) mountain focus (no. 39), representing the most ancient branch of the 0.PE2 phylogroup circulating in populations of common voles (Microtus arvalis). The study of distal branches of the plague tree can give additional data for comparative analysis of transformation from the enteropathogenic bacterium Yersinia pseudotuberculosis with a fecal-oral route of transmission into hypervirulent vectorborne Y. pestis that, as a rule, causes a generalized highly lethal septic infection. The data of 25-locus multiple-locus variable-number tandem-repeat analysis (MLVA25) typing of Y. pestis subsp. Caucasica strains (3) suggest that the strains from the East Caucasian (previous name, Dagestan) mountain focus

Results

Conclusion