Effects of tiotropium combined with noninvasive positive pressure ventilation on pulmonary function and levels of serum APN, PAB and SOD in senile patients with COPD and respiratory failure

Abstract

Objective To investigate the effects of tiotropium combined with noninvasive positive pressure ventilation on pulmonary function and levels of serum adiponectin (APN), superoxide dismutase (SOD) and prealbumin (PAB) in senile patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods Sixty-six senile COPD patients with respiratory failure were divided into control group and study group according to random number table method, with 33 cases in each group. The control group was treated by conventional therapy, the study group was treated with tiotropium bromide + noninvasive positive pressure ventilation on the basis of conventional treatment. Both groups were treated for 1 month. Lung function indexes [forced vital capacity (FVC), the first 1 s forced expiratory volume (FEV1), FEV1/FVC], serum APN, SOD, PAB levels, blood gas indexes [carbon dioxide partial pressure (PaCO2), oxygen partial pressure (PaO2)]at the time of admission and after treatment were statistically analyzed. Results After treatment, the levels of FVC, FEV1 and FEV1/FVC of the two groups increased, and those in study group was higher than those in control group, the difference was statistically significant (P 0.05); after treatment, the PaCO2 of study group was lower than that of control group, the PaO2 was higher than that of control group, the differences were statistically significant (all P<0.05). The fatality rate in study group (3.03%) was lower than that in control group (24.24%), the difference was statistically significant (P<0.05). Conclusions Noninvasive positive pressure ventilation combined with tiotropium has significant effect on the treatment of COPD complicated with respiratory failure in senile patients. It can improve lung function, blood gas status and levels of serum APN, PAB, SOD and can reduce disease fatality rate, which is worthy of promotion. Key words: Tiotropium bromide; Noninvasive positive pressure ventilation; Pulmonary function; Adiponectin; Prealbumin; Superoxide dismutase