Effects of thiazide bromide and noninvasive positive pressure ventilation on blood gas analysis, inflammatory factors and APN, SOD and PAB levels in elderly patients with COPD and respiratory failure

Abstract

Objective To study and analyze the effects of tiatoxonium bromide and noninvasive positive pressure ventilation on blood gas analysis, inflammatory factors and adiponectin (APN), superoxide dismutase (SOD) and prealbumin (PAB) levels in elderly patients with chronic obstructive pulmonary disease (COPD) and respiratory failure. Methods Eighty-two elderly patients with COPD and respiratory failure admitted to our hospital from February 2017 to February 2018 were studied.They were divided into experimental group and control group according to random number table method.The control group was treated with routine treatment and non-invasive positive pressure ventilation, while the experimental group was treated with thiazide bromide on the basis of the control group, and both groups were treated with 30 days treatment.Lung function indexes, blood gas analysis indexes, inflammatory factors, APN, SOD and PAB levels of the two groups were compared before and after treatment. Results Forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC levels in the experimental group after treatment were higher than the control group (all P<0.05). After treatment, the PaCO2 level of the experimental group was lower than the control group, while the PaO2 level was higher than the control group (all P<0.05). Serum IL-8 and IL-13 levels in the experimental group were lower than the control group after treatment (all P<0.05). Serum APN, SOD and PAB levels in the experimental group after treatment were higher than in the control group (all P<0.05). Conclusions Tiatoxonium bromide and non-invasive positive pressure ventilation can significantly improve lung function and blood gas analysis in elderly patients with COPD and respiratory failure, and also help reduce inflammatory reaction and improve APN, SOD and PAB levels.Which is worthy of clinical promotion and application. Key words: Pulmonary disease, chronic obstructive; Respiratory failure; Thiazide bromide; Ventilation, non-invasive positive pressure; Inflammatory cytokines