Clinical observation of noninvasive positive pressure ventilation on acutely exacerbating chronic obstructive pulmonary disease with respiratory failure

Abstract

Objective To study the effects of noninvasive positive pressure ventilation on acutely exacerbating chronic obstructive pulmonary disease (COPD) complicated by respiratory failure. Methods One hundred patients with acutely exacerbating COPD complicated by respiratory failure were selected and divided into observation group (50 cases) and control group (50 cases) according to treatment methods. Patients in observation group were given noninvasive positive pressure ventilation on thebasis of controlling infection, inhaling oxygen and drugs administration; and patients in control group were only given basic treatment, including controlling infection, inhaling oxygen and drugs administration. The clinical effects of the two groups were compared. Results The blood gas indexes (PaO2, PaCO2) in observation group were all superior to those in control group at 1, 3, 5 d after treatment (all P<0.05); the hospital stay in observation group was shorter than that in control group, the probability of return to hospital for retreatment in observation group was lower than that in control group, the differences were statistically significant (all P<0.05). Conclusions Noninvasive positive pressure ventilation can shorten the recovery time and reduce the probability of returning to hospital again in acutely exacerbating COPD patients with respiratory failure. Key words: Chronic obstructive pulmonary disease, acute exacerbation; Respiratory failure; Noninvasive positive pressure ventilation