Noninvasive positive pressure ventilation for respiratory failure secondary to acute exacerbations of COPD: a clinical analysis of 46 cases

Abstract

Objective To evaluate the efficacy of noninvasive positive pressure ventilation for respiratory failure secondary to acute exacerbations of COPD. Methods From January 2007 to December 2009, 92 patients were randomly assigned to receive conventional therapy alone (control group, 46 patients) or the same therapy plus noninvasive positive pressure ventilation (study group, 46 patients). The efficacy was compared between the two groups. Results After treatment, observe groups have better therapeutic efficacy than control groups in degrading PaCO2, degrading respiratory frequency, and elevating PaO2. Conclusions Noninvasive positive pressure ventilation for respiratory failure secondary to exacerbations of COPD can effectively decrease PaCO2 level and respiratory rate and increase PaO2 level. It has a better efficacy. Key words: Noninvasive positive pressure ventilation; Chronic obstructive pulmonary disease; Acute exacerbation; Respiratory failur