Effects of pregnancy induced hypertension on lipid metabolism and bilirubin metabolism in term neonates

Abstract

Objective To observe the effects of pregnancy induced hypertension on lipid metabolism and bilirubin metabolism in term neonates. Methods 200 term neonates were selected and divided into the two groups,100 cases whose mother were healthy were control group and another 100 cases whose mother had gestational hypertension were observation group. Birth weight, measured in cord blood triglyceride(TG),total cholesterol(TC)levels, high density lipoprotein(HDL-C),low density lipoprotein(LDL-C), adiponectin(APN)level were recorded. Results Birth weight of the observation group had significantly lower birth weight(2 927±492)g,than the weight of the control group(3 452±348)g.The incidence of lower birth weight was higher than in the observation group.TG,LDL-C levels of the observation group were(0.6±0.24)mmol/L,(1.95±0.25)mmol/L,were higher than those of the control group[(0.39±0.17)mmol/L,(1.95±0.25)mmol/L].There was a statistically significant difference between the groups(t=12.35,2.35,P<0.01 or P<0.05).HL-C and APN of the observation group were lower than those of the control group(t=1.79,7.00,all P<0.05).Bilirubin after borned 24 hours,48 hours,72 hours and bilirubin peak of the observation group were(8.64±2.17)mg/L,(11.06±3.12)mg/L,(10.32±2.47)mg/L,(12.04±2.13)mg/L and were higher than those of the control group[(3.06±0.94)mg/L,(6.98±1.56)mg/L,(7.26±1.89)mg/L,(9.64±1.98)mg/L](t=23.48,11.65,9.84,8.27,all P<0.01). Conclusion Maternal PIH may affect birth weight, lipid metabolism and bilirubin metabolism. Key words: Pregnancy induced hypertension; Infant, newborn; Blood, Lipid; Bilirubin