EffectS of neonatal hepatitis B vaccination and its once more immune effect in low or no responders

Abstract

Objective To investigate the immune effect of neonatal hepatitis B vaccination and its once more immune effect in low or no responders .Methods Screening Songzi city MCH 2 000 cases of hepatitis B vaccine 7-12 months baby＇s first immunization effect ,analyze the impact of the prime factors for early response in children with low or no free choice 10μg Hansenula yeast recombinant hepatitis B vaccine or 5μg hepatitis B vaccine （ HepB-SC） , carried revaccination（Immune again）,then analyzed the effect of free 1,3 times.Results （1） Primary immune response rate of neonatal hepatitis B vaccine in 2 000 cases was 92.2%,the average anti-HBsGMC was （321.88 ± 100.45） IU/L,in which the HBsAg positive persons and birth in the township hospital neonatal response rate was low that had a statistically significant （χ2 =30.61,47.58,all P 〈0.05） difference with the children whose parents＇HBsAg was negative and borned in hospitals above the county level;（ 2 ） GMC content was increase in once more immune at 1,3 times than before,the difference was statistically significant （t=98.32,102.15,all P〈0.05）,and the 3 time is higher than the 1 time once more immuneof levels of GMC ,the difference was statistically significant （ t=98.55,102.33,all P〈0.05）,content of GMC is higher in once more immune of Hansenula hepatitis B vaccine at 1, 3 times when compared with the recombinant hepatitis B vaccine , the difference was statistically significant （ t =104.11,124.31,all P〈0.05）.Conclusion Low and non-responders’proportion is high in the children whose par-ents＇HBsAg is positive and be born in the primary hospital ,which has a higher response rate after once more immune , Hansenula hepatitis B vaccine has a better immune effect . Key words: Hepatitis B vaccines; Immunity; Neonatal screening