Evaluation on the effect of Immunization with hepatitis B vaccine in healthy people

Abstract

Objective To evaluate the effect of hepatitis B vaccination in healthy people and provide the basis for developing immunization strategy.Methods Two-stage sampling method was designed.A questionnaire survey was conducted among 2038 permanent residents aged 1-59 years old from 8 villages.Intravenous blood samples were taken and detected for hepatitis B virus serum markers by ELISA.Results The surveyed inoculation rate of hepatitis B vaccine was 50.54%,with the rate being higher in urban area than in rural area and being higher in men than in women.The vaccination rate decreased gradually from the youngest group(98.14%)to the oldest group(0.95%).The scattered and nursery children had the highest rate (96.58%and 98.77%),followed by students(87.17%),farmers had the lowest rate(4.26%).HBsAg positive rates increased gradually from the youngest group to the oldest one(0%-10.48%).Anti-HBs positive rates were between 14.58%-50.18%,with 15-year old group having the lowest rate(14.58%).The reported incidence rate of hepatitis B was the highest in 1999(67.0660/100 000)from 1990 to 2007,and showed a descending tendency since then.The average reported incidence rate wag lower than 4.673 1/100 000 among age groups 14 years and under and was higher than 32.0789/100 000 among age groups 15 years and above between 2005 and 2007.HBsAg and anti-HBs positive rates after vaccination with plasma-derived hepatitis B vaccine(0.98%and 39.54%)had no statistical difference from those vaccinated with genetically engineered vaccine(0.49%and 43.28%)(x2=0.107,P=0.744;x2=1.004,P=0.316).ConclusionsWe should continue hepatitis B vaccination for neonates,expand adult hepatitis B vaccination and allocate more resources of hepatitis B prevention to the rural. Key words: Hepatitis B vaccines; Hepatitis B surface antigens; Hepatitis B antibodies:Vaccination