Seroepidemiologic investigation and analysis of the hepatitis B virus in suining of Sichuan.

Abstract

Objective To understand the situation of the hepatitis B virus infection in Suining,Sichuan, and to evaluate the results of promoting the hepatitis B vaccine immunization strategy in the neonatal after 1992. Methods A multi-stage stratified random sampling method was adopted, and selected the counties according to administrative region and the economic level. A township (street offices) was randomly selected from each county, in each township selected randomly a village. The family as the unit carried out a questionnaire for 1-59 year old group, and collected blood to detect the HBsAg,anti-HBs and anti-HBc by ELISA. Results A total of 1468 human serum were collected for detect; The positive rate of HBsAg among the crowd was 14.78%, the positive rate of anti-HBs was 39.17%, the infection rate of HBV was 72.68%. HBsAg positive rate of the upper age group was 30 to 34-year-old group (27.59%) and the lowest was 0-4-year-old group (2. 06% ); HBV infection rate was the highest 55-59-year-old group (93.13%) and the lowest was 5-9 year-old group (44. 2%), there were differences in the sex, age,occupation and geographic prevalence rate of HBV infection signs. Conclusion In Suining, Sichuan region, people HBV infection was high, the crowd HBsAg-positive rate was still higher than the national average, but the epidemiological characteristics of hepatitis B among the crowd had changed, to promote the use of hepatitis B vaccine had dramatically reduced the target population ( ≤ 14 year-olds) in HBsAgpositive rate and HBV infection. Key words: Hepatitis B; Seroepidemiologic studies