Effects of narrow-band UVB combined with tacrolimus ointment in the treatment of vitiligo and its influence on IL-17 and IL-22 in peripheral blood

Abstract

Objective To investigate the effect of narrow-band UVB combined with tacrolimus ointment in the treatment of vitiligo, and its influence on IL-17 and IL-22 in peripheral blood. Methods 100 patients with vitiligo were selected as study subjects, and they were divided into the control group and observation group according to the random number table method, 50 cases in each group. The control group was given 0.1% tacrolimus ointment, the observation group was treated with narrow-band UVB combined with 0.1% tacrolimus ointment. After 6 months of treatment, the clinical treatment effect of the two groups was observed. The levels of serum IL-17 and IL-22 were detected by ELISA, the differences between before and after treatment were compared between the two groups. Results The cure rate, effective rate of the observation group were 74.0%, 96.0%, respectively, which were significantly higher than 62.0%, 84.0% of the control group, the differences were statistically significant(χ2=3.125, 2.897, all P 0.05). After treatment, the levels of IL-17 and IL-22 in the two groups significantly decreased(t=3.454, 3.032, all P<0.05), which in the observation group were lower thanthose in the control group(t=3.867, 2.665, all P<0.05). Conclusion Narrow-spectrum UVB combined with tacrolimus ointment has good clinical effect on vitiligo, which can effectively improve the local immune response. Key words: Vitiligo; Ultraviolet therapy; Tacrolimus binding proteins