Abstract
Little is known of the influence of nutritional status on cytochrome P450 (CYP) 1A2 activity in elderly patients. Thirty elderly institutionalised patients with malnutrition (group A, aged 88±5years) and 24 without (group B, aged 81±9years) were included. Malnutrition was defined as weight loss of >10% over the previous 6months and/or a body mass index (BMI) <21kg/m2 and albuminaemia ≤32g/L. CYP1A2 activity was evaluated by the plasma paraxanthine/caffeine (PAX/CAF) metabolic ratio. The plasma PAX/CAF metabolic ratio was similar in both groups regardless of nutritional status (0.34±0.13 [A] versus 0.30±0.11 [B]; p=0.11). The CYP1A2 metabolic ratio was not correlated to either BMI, serum albumin or renal clearance. CYP1A2 activity, as measured by the plasma PAX/CAF ratio, was not influenced by nutritional status in elderly patients.
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