EFFECTS OF CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS OPERATED FORGASTRIC CANCER

Abstract

The purpose of the study is the assessment of the effect of the correction of endothelial dysfunction on the indices of the function of vascular endothelium and hemostasis system in gastric cancer patients. There were examined 102 patients with advanced gastric cancer at the II (T1-3N1-2M0) and III (T2-4N2-3M0) clinical stage. The control group included 40 healthy subjects matched by age and gender. We evaluated the relationship degree of endothelial dysfunction and its correction results with the outcomes of the treatment after surgery. Patients were divided into 2 groups - the standard of reference (55) and the additional use of means of vascular endothelial function correction (47 patients). Compared group had no significant difference in general and oncological parameters. Additional treatment included the use of the drug L-arginine at a dose of 1.0 g / day in combination with an ACE inhibitor. Statistical analysis envisaged the determination of the degree of significance of differences between groups of indices on the method of Mann-Whitney. As an boundary indication of the presence of the statistical significance there was accepted p < 0.05. There was revealed the presence of significant differences in the degree of damage (the number of circulating endothelial cells) and violations of the functional state of the vascular endothelium in patients exposed standard (main group) treatment and the use of other methods of correction of endothelial dysfunction. In the study group there was also achieved significant correction of hemostasis.