Comparative analysis of the metabolic activity of vascular endothelium in patients with pulmonary tuberculosis combined with diabetes mellitus and without it

Abstract

Aim: comparison indicators of the metabolic activity of the vascular endothelium in patients with pulmonary tuberculosis (TB) combined with diabetes mellitus (DM) and without it. Materials and methods: The study involved 56 patients with pulmonary TB combined with diabetes (main group). The comparison group included 76 patients with pulmonary TB without diabetes mellitus. The level of endotelin-1 (E-1) and von Willebrand factor antigen (vWF) was determined by ELISA. The level of nitric oxide (NO . ) determined with Griess reagent. Results: It has been found that the level of NO . and E-1 in patients compared groups was essentially similar. The level of NO . was significantly reduced, as in patients with pulmonary TB combined with DM (41,4 ± 0,8 at a rate of 50,5 ± 1,4mkM; p The level of vWF ranged from normal variation in patients with pulmonary TB without DM (92,3 ± 3,4 at a rate 100,0±5,0%) and significantly higher than it (1.5 times) in patients with combined DM (149,5 ± 4,2 at a rate 100,0±5,0%; p Conclusion: Opposite changes of two powerful mediators with the opposite vector effects on vascular tone indicates the presence of endothelial dysfunction in patients with TB combined with DM. Such changes create preconditions for violations of the microcirculation.