Abstract
Andira inermis stem bark has been used by herbal practitioners in the treatment of many ailments. Its Pharmacological activities include Anti-oxidant activity, haematological activities, hypoglycaemic activity and antiplasmodia activities. This study seeks to evaluate the effect of aqueous stem bark extract of Andira inermis on some gonadal hormones, sperm count and sperm motility. Thirty-two male Wistar rats weighing 100-120g were randomized into Four (4) groups consisting eight (8) rats each. The animals were allowed to undergo acclimatization for 14days. Animals in group 1 served as the control, group 2, 3 and 4 were the treatment groups. Group 1 received free animal feed and water. Group 2, 3 and 4 received 100, 250 and 500mg/kg aqueous extract of Andira inermis stem bark administered orally daily for 90days. Twenty-four hours after the last administration, rats were sacrificed and cardiac puncture was used to collect the blood for centrifugation. The extract produced a significant (P<0.05) increase in serum testosterone, follicle stimulating hormone, and luteinizing hormone respectively at 100mg/kg body weight but had no significant effect on luteinizing hormone and testosterone hormone at 250mg/kg and 500mg/kg bodyweight compared to normal control. At 250mg/kg and 500mg/kg treatment, follicle stimulating hormone was significantly decreased compared to control. Sperm counts decreased significantly from 22.13±0.53million/ml to 13.00±1.16 million/ml and sperm motility from 11.25±0.41 million/ml to 8.00 ± 0.59 million/ml after treatment. Data was expressed as the mean ± SEM. Statistical comparisons between various treatment groups was determined using one-way analysis of variance (ANOVA).
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