Abstract
Effects of thyroidectomy and thyroxine supplement were studied on amino acid incorporation into secretory granules obtained from rat anterior pituitary slices incubated with alanine-14C in vitro.Thyroidectomy stimulated the incorporation of alanine into TSH-rich granules specifically, and this stimulation was suppressed by thyroxine administration.The same suppressive effect was seen when T4 was added to pituitary slices in vitro.Since T4 dose administered in vivo or in vitro was in the range of physiological level, the effect mentioned above could be considered to be of physiological significance.It was assumed that pituitary TSH synthesis is continuously carried on under the influence of circulating thyroid hormone level, and through this mechanism the feed-back relationships are maintained, at least partly, between the thyroid and the anterior pituitary.
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