Effect of radiofrequency ablation of low temperature plasma knife in the treatment of 32 cases of early glottal carcinoma

Abstract

Objective To investigate the effect and recurrence rate of radiofrequency ablation of low temperature plasma knife in the treatment of patients with early glottal carcinoma. Methods A total of 64 cases of early glottic carcinoma in the People's Hospital of Shanxi Province from February 2012 to January 2016 were divided into observation group and control group according to the different treatment schemes, with 32 cases in each group.The observation group was treated with radiofrequency ablation of low temperature plasma knife, and the control group was performed with routine larynx cleft surgery.The surgical related indicators and postoperative complications of the two groups were recorded.The phonetic changes (amplitude perturbation, fundamental frequency perturbation and harmonic noise ratio) before and 6 months after operation of two groups were compared.After 2 years of follow-up, the recovery of vocal mucosa in the two groups after 1 year of operation and the recurrence rate of 6 months, 1 year and 2 years after operation of the two groups were statistically recorded. Results The intraoperative blood loss in the observation group was less than that in the control group(P 0.05). After operation, the amplitude perturbation and the fundamental frequency perturbation in the observation group were lower than those of the control group, and the harmonic noise ratio was higher than that of the control group, the difference were statistically significant (t=18.618, 4.258, 2.579, all P<0.05). In the observation group, the recurrence rates at 6 months, 1 year and 2 years after operation were lower than those in the control group(χ2=4.598, 6.335, 4.730, all P<0.05). Conclusion Radiofrequency ablation of low temperature plasma knife in the treatment of patients with early glottal carcinoma can significantly reduce the intraoperative blood loss, shorten the operation time and observation time of postoperative hospital stay, and significantly reduce the incidence of postoperative complications and recurrence rate.It can also improve the patients' voice, and promote the recovery of vocal cord mucosal smooth.Besides, it has remarkable effect, and it has important significance in clinical treatment. Key words: Laryngeal neoplasms; Glottis; Ablation technigues; Cryosurgery; Larynx dehiscence; Comparative effectiveness research