Short-term and long-term efficacy of radiofrequency ablation combined with chemotherapy for advanced non-small cell lung cancer

Abstract

Objective To study the short-term and long-term efficacy of radiofrequency ablation combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Methods A total of 60 patients with advanced non-small cell lung cancer treated from January 2013 to January 2015 in Foshan First People’s Hospital were selected. The 60 patients were randomly divided into control group (n= 30) and observation group (n= 30). The control group received GP regimen chemotherapy and the observation group received radiofrequency ablation and GP regimen chemotherapy. The short-term curative effect, cancer pain score, cancer-induced fatigue score, medium and long term survival rate, local recurrence rate and quality of life score were compared between the two groups. Results The objective remission rate and total effective rate of the observation group were higher than those of the control group (P< 0.05). The scores of resting pain and motor pain after teatment in the two groups were lower than those before treatment (P< 0.05), and the score of resting pain and motor pain in the observation group were lower than those in the control group (P< 0.05). After treatment, the score of cancer-related fatigue in the observation group was lower than that in the control group (P< 0.05). The 1-year and 3-year survival rates of the observation group were higher than those of the control group (P< 0.05). The local recurrence rate of the observation group was lower than that of the control group 1 and 3 years after treatment (P< 0.05). The scores of physical health, mental health, social function and general feeling in the observation group were higher than those in the control group (P< 0.05). Conclusions In patients with advanced non-small cell lung cancer, chemotherapy combined with radiofrequency ablation can obtain good short-term curative effect, alleviate the pain and fatigue due to cancer, and improve the survival rate of patients in the medium and long term. The local recurrence is reduced and the quality of life is improved. Key words: Non-small cell lung cancer; Chemotherapy; Radiofrequency ablation; Short term effect