Clinical effects of HBO-assisted chemotherapy on the patients with advanced non-small cell lung cancer and their life quality

Abstract

Objective To investigate the clinical efficacy of HBO-assisted chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC) and the effects on the scores of life quality Methods Eighty-eight patients with advanced NSCLC admitted into the hospital from July 2015 to July 2017 were divided into the observation group and the control group in accordance with the odd and even number of patient admission, each consisting of 44 patients. The patients in the control group were treated with chemotherapy and expectant treatment, while the patients in the observation group received HBO in addition to the treatment given to the control group. After 3 courses of treatment, short-term effects were compared between the patients of the 2 groups. Two years after treatment, Kaplan-Meier analysis was performed to evaluate the long-term treatment effects through the access of one-year survival curve. Twenty-eight days after treatment, acute and sub-acute toxic scores as well as the scores of life quality before and after treatment were closely observed and compared between the patients of the 2 groups. Results Twenty-eight days after treatment, various dimensions of life quality and total scores all significantly increased in the patients of both groups, with those of the observation group being obviously higher than those of the control group(all P 0.05). Conclusion HBO-assisted chemotherapy in the treatment of the patients with NSCLC could obviously improve clinical efficacy and scores of life quality, and alleviate acute and sub-acute toxic reactions as well. Key words: Hyperbaric oxygen; Advanced non-small cell lung cancer; Chemotherapy; Clinical efficacy; Life quality scale